- 2019-09-19 13:52
- 作者: 尹聪颖
9月4日， 以“科技改变城市，智慧创造生活”为主题的第二届中澳科学未来会议在北京圆满召开。会议期间，悉尼新南威尔士大学(UNSW Sydney)化学学院的马蒂娜·斯滕泽尔教授接受与会媒体采访，玛蒂娜教授是近90年来第一位获得新南威尔士州皇家学会利弗希德格奖章(Royal Society of NSW's Liversidge Medal)的女性，她分享了在个性化癌症治疗方法研究中的研发感悟。
GOOGLE TRANSLATE VERSION:
Conversation with experts in nanomedicine at the University of New South Wales in Sydney to see the scientific opportunities brought about by China-Australia cooperation
The release of each scientific research is inseparable from the collaboration of multiple disciplines, multiple research teams, and even national research representatives. Therefore, the international exchange of scientific research capabilities is very helpful for concentrating the advantages of scientific research resources and realizing scientific research progress.
On September 4th, the 2nd Sino-Australian Science Future Conference on the theme of “Technology changes the city, wisdom creates life” was successfully held in Beijing. During the conference, Professor Martina Stenzel of the Department of Chemistry at the University of New South Wales (UNSW Sydney) was interviewed by the media and shared her insights into the research and development of personalized cancer treatment methods.
Nanomedicine, let cancer treatment go further
“What we hope to do is to make anticancer treatment more effective.” Professor Martina Stenzel told HC3i that we are trying to add anticancer drugs to the nanoparticles so that it can accurately resist.
The cancer drug is delivered to the target location where we need it to be delivered.
The original intention of the development of this drug is that in the traditional cancer treatment, many times the drug cannot reach the tumor site accurately, but will reach other healthy parts of the body, which will bring a series of serious side effects. Through the use of new materials such as nanoparticles and anti-cancer drugs, combined with targeted therapy technology, anticancer drugs can accurately hit the core of the tumor and further improve the effective delivery of the drug.
The specific approach is:
The first step, based on targeted care, ensures that anticancer drugs actually reach the core of the cancer cell. That is: whether the receptor is first located on the surface of the cancer cell, and the receptor as a marker is unique to the cancer cell, which is equivalent to marking it, and then wrapping the anticancer drug in the nanoparticle to make it The surface receptor can be found to match it. Therefore, targeted therapy is equivalent to giving cancer cells a target that can be applied in real time on almost any type of cancer.
In the second step, nanomaterials are used to increase the rate of drug arrival in cancer cells. Why is it related to nanomedicine later? Because some new drugs are targeted at specific cancers, the constituent molecules may be less stable. After entering the body, it may be degraded by the body, and even if it is too late to reach the cancer cells, it has already been broken down by the body. Therefore, we use nanotechnology particles as a new way to encapsulate drugs with nanoparticles, so that drugs can reach the depths of cancer cells.
"In short, this new nanoparticle-encapsulated anticancer drug can reach the core of cancer cells without harming other healthy cells," said Professor Martina Stenzel.
Behind medical progress, there is interdisciplinary communication
The rise of personalized medicine has made more and more medical experts realize that the development of new drugs is not only a matter of medicine and pharmacy experts, but also needs to introduce more experts in fields such as chemistry, materials science, AI, statistics.
From the perspective of nanomedicine, there are already a number of nanopharmaceuticals on the market, such as the two major nano drugs to market breast cancer nano-drugs - such as Abraxane® and Doxil® Abraxas and Doceo. At the same time, experts in the field of nanomedicine are also using drug research to treat nanomedicine for Parkinson's disease and diabetes; nanomedicine is used to treat resistance to antibiotics. "We also hope to solve some of the resistance and resistance to antibiotics through nanoparticles," said Professor Martina Stenzel.
In this interdisciplinary study, everyone is working toward the same common goal, and everyone needs to contribute their own strength. "You can't be too conceited. You need to listen to the opinions of experts in other fields. It is very important that you go to learn with them." Professor Martina Stenzel said that especially in the field of nanoscience, it is impossible. Everyone is a team leader, you are just a part of the team.
Sometimes some scientists prefer to fight alone, or just do what they like, but joint research requires different people to work together.
In addition, there is another problem for different professional researchers: that is, to study and learn the language of others. “For example, one of my big problems in this research is that it is very easy for me to communicate with colleagues in the same field of study. However, if we communicate with people in different fields, even if we all speak English, dome questions will still exist," said Professor Martina Stenzel.
Chinese opportunities in nanomedicine
“China has always been one of the world leaders in nanomedicine in nanoscience and nanomedicine.” Professor Martina Stenzel said that I have seen many, very good results in China. We can learn a lot from the continuous strengthening of cooperation between the two sides, and the two sides can better achieve cooperation and exchanges.
“China has two areas of particular leadership in nanomedicine,” she said.
First, China's theoretical calculation of nanoparticles is very good. China can already predict in advance how nanoparticles will act and how they will behave. Therefore, China has done a good job in theory.
Second, Chinese hospitals are also very open to these new ideas and are happy to try. This is actually quite different from traditional medicine, but Chinese hospitals will be interested and willing to try.
Cross-border exchanges to explore more research opportunities
The open attitude in China's scientific research field has led to more and more international research cooperation models and projects.
The University of New South Wales in Sydney and the Institute of Science and Technology Strategic Consulting of the Chinese Academy of Sciences reached a partnership in 2009.
Today, there is considerable cooperation between the University of New South Wales in Sydney and China, especially in nanoscience. “Now our university has established partnerships with more than 70 Chinese universities, research institutes and government departments, and we share a lot of common publications,” said Professor Martina Stenzel.
Cooperation, we can produce more and better scientific research results. On this point, the two sides have reached consensus. At the same time, the two sides also have some cooperation on the fund. The University of New South Wales in Sydney also provides seed funding for some new research projects in China. Especially in nanoscience.
Promoting scientific and technological progress is the ideal of every scientist. This is the consensus of every scientist in the world. With the continuous opening of China's scientific research field, more and more scientists will come to China to explore more scientific research opportunities. This is not only an opportunity for China's scientific development, but also a contribution to the world's scientific and technological progress.